The codeine and promethazine in Promethazine with Codeine Oral Remedy may possibly raise the frequency of seizures in sufferers with seizure Issues, and could raise the threat of seizures taking place in other medical options affiliated with seizures.
Renal impairment: The kidney is the major route of elimination, so pharmacokinetics is altered in clients with renal impairment. Consequently, clinicians need to prescribe codeine at a minimized dose or with for a longer time dosing intervals.
Don't flush prescription drugs down the rest room or pour them into a drain unless instructed to take action. Correctly discard this solution when it's expired or now not desired. Speak to your pharmacist or regional waste disposal enterprise.
The concomitant utilization of Promethazine with Codeine Oral Option with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor could bring about reduced codeine levels, greater norcodeine amounts, and less metabolism by using 2D6 with resultant decreased morphine levels. This may be connected with a decrease in efficacy, and in some patients, may possibly lead to signals and signs and symptoms of opioid withdrawal.
This product or service may perhaps consist of inactive elements, which can result in allergic reactions or other difficulties. Talk with your pharmacist For additional facts.
In case you are having surgery, which includes dental operation, convey to the medical doctor or dentist that you're using promethazine.
Lie down with your remaining side and lift your ideal knee in your upper body. (A remaining-handed human being should really lie on the best side and lift the left knee.)
The concomitant use of Promethazine with Codeine Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor might cause lessen codeine degrees, larger norcodeine stages, and Promethazine codeine syrup fewer metabolism by using 2D6 with resultant lower morphine amounts. This can be associated with a lower in efficacy, and in some patients, may possibly bring about indications and symptoms of opioid withdrawal.
You should definitely Keep to the directions diligently, since continuing constipation can result in much more really serious issues.
For the duration of pregnancy, this medication should be used only if clearly necessary. Explore the risks and Rewards together with your medical professional.
Usually do not use this item to deal with cold indications in youngsters young than 6 years Until precisely directed from the doctor. Some items (including very long-performing tablets/capsules) will not be suggested for use in youngsters younger than 12 a long time. Ask your doctor or pharmacist For additional specifics about utilizing your solution securely.These products and solutions never overcome or shorten the size in the popular chilly and may bring about major Unwanted side effects. To reduce the chance for critical Unwanted side effects, meticulously adhere to all dosage Instructions. Don't use this products to create a baby sleepy. Never give other cough-and-chilly medication that might comprise a similar or identical components (see also Drug Interactions section). Request the medical professional or pharmacist about other approaches To alleviate cough and chilly signs or symptoms (for instance consuming adequate fluids, utilizing a humidifier or saline nose drops/spray).
Speak with your health care provider When you've got any questions about using codeine or regarding how this drugs may well affect your infant.
Most MAO inhibitors must also not be taken for two months just before therapy using this type of medication. Ask your health practitioner when to get started on or cease having this medication.
The following major adverse reactions are described, or described in bigger detail, in other sections: